Abstract Background Colorectal cancer (CRC) is the third most prevalent cancer worldwide. with the tumor microenvironment (TME) playing a crucial role in its progression. Aggregated autophagy (AA) has been recognized as a factor that exacerbates CRC progression. This study aims to study the relationship between aggregated autophagy and CRC using single-cell sequencing techniques. https://icemanvideoesgames.shop/product-category/sega-saturn/